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devonwhite
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GABA v Gabapentin

Hi All,

My son was recently diagnosed as having an auditory processing disorder and language-based learning disability. The neurologist said he has apraxia. He was then given both waking and sleeping EEG and found to be having small seizures in his occipital lobe. The doctor called them cognitive seizures (his name for it, I think).

He recommended lowering use of fast moving video games and getting regular sleep. The next step, if that doesn't bring his EEG back to normal is to move to low doses of gabapentin. However, my wife and I are interested in moving forward a little more aggressively. We're wondering if GABA would be a decent substitute for gabapentin. As well, do you have any other suggestions (based on this very limited information)?

Thanks!

d


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Alex
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Re: GABA v Gabapentin

Hi dude,
Apologies for delay,
Not knowing how old the person is or anything about them makes it difficult to respond usefully with regard to any third party, so I should add that this is not medical advice, but in general dosing anybody up with anything unless it's absolutely necessary is not wise. There are many remedial  steps we can take first, most of which involve lifestyle changes. Gut bacteria manipulation can do a lot to improve many conditions. Bear in mind also that 'regular sleep' is not as healthful as natural sleep (that is, sleeping when we are tired and waking up naturally, when we are not); and that everybody's favorite drug, Caffeine, is a GABA inhibitor.

Possible useful things about GABA:
GABA in the body (for example from diet) does not cross the blood-brain barrier. Phenibut, or beta-phenyl-gamma-aminobutyric acid Hcl, is a designer GABA analog which can cross the barrier and act on GABA receptors. Another GABA analog supplement is picamilon, or nicotinoyl-GABA. Picamilon is made by adding niacin to the GABA molecule. Once picamilon crosses the barrier, the niacin molecule is cleaved off, leaving pure GABA.

May be useful:
http://www.nature.com/npp/journal/v37/n … 2142a.html
https://clinicaltrials.gov/ct2/show/NCT00094510
http://www.rxlist.com/neurontin-drug/cl … cology.htm

Best,
AR


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